The prospect of silencing disease using RNA interference.
نویسندگان
چکیده
The discovery of RNA interference (RNAi), an endogenous cellular gene-silencing mechanism, has already provided a powerful tool for basic science researchers to study gene function. The subsequent finding that RNAi also operates in mammalian cells has generated excitement regarding potential therapeutic applications. In this article we discuss the basic mechanism of RNAi and the therapeutic opportunities and obstacles for harnessing RNAi for therapy of human disease.
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ورودعنوان ژورنال:
- JAMA
دوره 293 11 شماره
صفحات -
تاریخ انتشار 2005